7  Curriculuum vitae

7.1 Personnal information

Name:
Matthieu Caruel
Citizenship:
French
Date of birth:
September 28th 1983
Current position:
Associate Professor, Faculté des Sciences et Technologie, Université Paris-Est Créteil
Research affiliation:
Laboratoire Modélisation et SImulation Multi Echelle (MSME, CNRS UMR 8208)
Address:
61, avenue du Général de Gaulle, 94010 Créteil, France
Email address:
Webpage:
https://research.caruel.eu

7.2 Education

2011
Doctor of Phylosophy, Ecole Polytechnique, Laboratoire de Mécanique des Solides (LMS)
  • Title: “Mechanics of Fast Force Recovery in Skeletal Muscles”
  • Supervision: Lev Truskinovsky and Jean-Marc Allain
  • Passed with very honorable distinction
2007
Master of Science, Ecole Polytechnique, Ecole des Mines de Paris
  • Passed first in class
  • Thesis: “Study of shape defects induced during the sintering of ceramic membranes for fuel cells”
  • Supervision: Jacques Besson
2007
Diplôme d’ingénieur des Ponts et Chaussées, Ecole Nationale des Ponts et Chaussées. Mechanical engineering Bachelor degree
2003
Admitted to Ecole Nationale des Ponts et Chaussées

7.3 Academic positions

Since 2014
Université Paris-Est Créteil; Associate Professor
  • Leading research program on multiscale biomechanical modeling
  • Teaching in the Mechanics department of the Faculty of Science and Technology
  • Pedagogical coordinator for the Physics undergraduate program (Mechanics track)
  • Coordinator of the experimental mechanics facility
2011-2014
Inria, MΞDISIM Project Team; Post-doc
  • Collaboration with D.~Chapelle and P.~Moireau group
  • Formulation, calibration and simulation of a jump-diffusion model of actin-myosin interaction in heart contraction
  • Formulation, calibration and validation of reduced model of cardiac fibers and the left ventricle
2008-2011
Ecole Polytechnique, Laboratory of Solid Mechanics; Ph.D.
  • Thesis: Stochastic modeling of collective conformational changes in molecular motors
  • Lecturer in undergraduate mathematics
2007-2008
Scientific and Technical Center for Building (CSTB); Engineer
  • Participation in the development of the national computational core for building energy performance certification
  • Liaison between public authorities and engineering firms for regulatory compliance

7.4 Synergistic Activities

7.4.1 Article reviews

2024
Scientific Reports, Communications Physics, Journal of elasticity, Acta Biomaterialia, Entropy
2022
eLife
2020
Proceedings of the Royal Society B, Proceedings of the National Academy of Sciences (with A. Houdusse), Vietnam Journal of Mathematics
2019
Physics Letters A
2018
Soft Matter
2016
Journal of Mechanics in Medicine and Biology

7.4.2 Grant expertise

2023
National Science Center (Poland), grant call “Preludium 2022” (PLN 70,000; 12 months)

7.4.3 Knowledge dissemination, popularization

2021
Article in “Ponts Alumni Magazine nº15”: La contraction cardiaque : la mécanique s’invite en pharmacologie

7.4.4 Scientific event organization

2020
Virtual Physiological Human (VPH 2020) Member of the scientific committee, Session on muscle modeling, Paris, Online
2018
MecaBio GDR meeting Session on interdisciplinary approach to muscle contraction modeling, Montpellier

7.4.5 Participation in PhD committees

2023
I Morotti (reviewer), The effect of omecamtiv mecarbil on the regulatory state of the cardiac thick filament. Università degli studi, Firenze (Italy), direction: M. Caremani, G. Piazzesi.
2023
Matteo Marcello (reviewer), Toward a better understanding of the mechanisms by which myofilaments control the activation of striated muscle. Università di Siena (Italy). Direction: M. Caremani, M. Linari.
2021
Giulio Bianchi (reviewer), Mechanical properties of cytoskeleton proteins studied in living cells by combining optical tweezers and deformability cytometry. Università di Siena (Italy). Direction: P. Bianco, M. Linari.
2021
Caterina Squarci (reviewer), The structural dynamics of titin in situ and its role in contraction and relaxation of the striated muscle, Direction: G. PIazzesi, P. Bianco
2021
Haythem Chelly (examiner), Influence de la rhéologie du substrat sur le rampement cellulaire. Université Grenoble Alpes. Direction: P. Recho, C. Verdier.
2020
Serena Governali (reviewer), Action mechanisms of physiological and pharmacological inotropic interventions on the slow/cardiac striated muscle, Università di Siena (Italy). Direction: M. Linari, M. Reconditi
2018
Hudson Borja Da Rocha (examiner), Collective effects in muscle contraction and cellular adhesion. Direction: L. Truskinovsky
2018
Irene Pertici (reviewer), The power output of a myosin II-based nanomachine mimicking the striated muscle, Università di Siena (Italy). Direction: V. Lombardi

7.5 Scientific activities and responsabilities

7.5.1 Research projects and team responsabilities

2018-
Coordinator of the cross-disciplinary research project MyoMech within the MSME laboratory. The objective of this project is to model the influence of myopathies and associated treatments on muscle function. It brings together researchers from three teams of the laboratory: the Theoretical Chemistry team (I. Navizet), the Mechanics team (F. Detrez), and the Biomechanics team (M. Caruel) and other research teams, notably the Inria MΞDISIM team and A. Houdusse (Institut Curie).
2018-2020
Responsible for the communication of the biomechanics team of the MSME lab: seminar organization, group meeting etc.

7.5.2 Mentoring

2022-2024
PhD thesis of Elaheh Saadat
  • Statistical Physics modeling of muscle activation
  • with S. Ruffo (SISSA, Trieste, Italy) and I. Latella (University of Barcelona)
2019-2023
PhD of Robin Manevy
  • Molecular Motors modeling using Molecular Dynamics methods
  • supervised with Isabelle Navizet (MSME, theoretical chemistry) and Fabrice Detrez (MSME, Theoretical Mechanics)
  • 1 article in preparation + conferences
2022
Master II Thesis of Louis-Pierre Chaintron
  • Thermodynamics of molecular motors
  • with Philippe Moireau and François Kimmig
2016-2019
PhD of François Kimmig
  • Multiscale modeling of muscle contraction : From stochastic dynamics of molecular motors to continuum mechanics
  • supervised with Dominique Chapelle (Inria, MΞDISIM)
  • 2 articles published on the PhD work + conferences
2015-2019
PhD of Florent Wijanto
  • Multiscale Mechanics of Soft Tissues
  • supervised with Jean-Marc Allain (Laboratoire de Mécanique des Solides, Ecole Polytechnique)
  • 2 peer-reviewed conferences
2019
Master II Thesis of Robin Manevy
  • Mechanical Modeling of Myosin Conformational changes
  • with Isabelle Navizet and Fabrice Detrez
2017
Engineer school internship
  • Tendon to bone interphase modeling
  • with Salah Naili (MSME)
2015
Master II thesis of Mohsen Nakhaei
  • Biophysical modeling of SNARE proteins
  • with Frédéric Pincet and Lionel Foret (Laboratoire de Physique Statistique, Ecole Normale Supérieure, Paris)

7.5.3 Main Scientific Collaborations

MSME Lab:

  • Isabelle Navizet and Fabrice Detrez: MyoMech transverse project. 1 PhD + 1 paper (in preparation) + 2 conference papers. Work on molecular dynamics simulations of molecular motors conformational changes
  • Salah Naili, Thibault Lemaire: 2 journal papers
Inria, MΞDISIM team
  • D. Chapelle: 1 PhD, 3 journal parpers and 4 conference papers
  • P. Moireau: 3 journal papers and 4 conference papers
  • J.~M. Allain: 1 PhD, 2 journal papers and 2 conference papers
National collaborations
  • Anne Houdusse (Iinstitut Curie, Paris): 1 paper in preparation on the work of R. Manevy
  • Lev Truskinovsky (PMMH laboratory, ESPCI, Paris): 6 journal papers
  • Frédéric Pincet (LPS, ENS, Paris): 2 journal papers + 1 conference paper
  • Tony Lelièvre and Julien Reygnier (CERMICS, Inria, ENPC, Paris), starting collaboration
International collaborations
  • James E. Rothman (Yale University, USA 2013 Nobel Prize winner in Physiology and Medicine): 1 journal paper
  • Stefano Ruffo (SISSA, Trieste, Italy) and Ivan Latella (University of Barcelona): 1 ongoing PhD and 1 paper in preparation
  • PhysioLab (University of Florence, Italy)

7.6 Pedagogical and administrative responsabilities

Teaching service of about 275 h/year

Since 2014
Teaching in Mechanics (solids and fluids) at undergraduate and Master level at UPEC
Since 2020
Responsible for the second-year undergraduate program in mechanics and of the mechanics technical facility.
Since 2020
Responsible for a doctoral course on scientific multiformat writing (LaTeX, Quarto, Pandoc).
Since 2022
Responsible for an ERASMUS+ partnership between UPEC and the University of Florence: Graduate course on the multiscale modeling of muscle contraction.
2017-2020
Development of a teaching curriculum name “Learning Differently” aimed at students from the ``sciences and technologies for industry and sustainable development’’ high school diploma. Implementation of innovative pedagogical methods for students with difficulties in mathematics.
2015-2020
Participation in the Centrale-Supélec competitive entry examination juries for a Physics-Chemistry exam in the Engineering Sciences track (PSI)
2014-2024
course on “Statistical mechanics: application to cell motility” in the Biomedical Engineering Master program at École Polytechnique.

7.7 List of publications

7.7.1 Article in peer reviewed journals

  1. CARUEL, Matthieu and PINCET, Frédéric, 2024. Dual-Ring SNAREpin Machinery Tuning for Fast Synaptic Vesicle Fusion. Biomolecules. 2024. Vol. 14, no. 5, p. 600. DOI 10.3390/biom14050600.
  2. CHAINTRON, Louis-Pierre, KIMMIG, François, CARUEL, Matthieu and MOIREAU, Philippe, 2023. A jump-diffusion stochastic formalism for muscle contraction models at multiple timescales. Journal of Applied Physics. 2023. Vol. 134, no. 19, p. 194901. DOI 10.1063/5.0158191.
  3. CHAINTRON, Louis-Pierre, CARUEL, Matthieu and KIMMIG, François, 2023. Modeling actin-myosin interaction: Beyond the Huxley–Hill Framework. MathematicS In Action. 2023. Vol. 12, no. 1, p. 191–226. DOI 10.5802/msia.38.
  4. KIMMIG, François, CARUEL, Matthieu and CHAPELLE, Dominique, 2022. Varying thin filament activation in the framework of the Huxley’57 model. International Journal for Numerical Methods in Biomedical Engineering. 2022. Vol. 38, no. 12, p. e3655. DOI 10.1002/cnm.3655.
  5. KIMMIG, François and CARUEL, Matthieu, 2020. Hierarchical modeling of force generation in cardiac muscle. Biomechanics and Modeling in Mechanobiology. 2020. Vol. 19, no. 6, p. 2567–2601. DOI 10.1007/s10237-020-01357-w.
  6. MANCA, Fabio, PINCET, Frederic, TRUSKINOVSKY, Lev, ROTHMAN, James E., FORET, Lionel and CARUEL, Matthieu, 2019. SNARE machinery is optimized for ultrafast fusion. Proceedings of the National Academy of Sciences. 2019. Vol. 116, no. 7, p. 2435–2442. DOI gmn5g3.
  7. CARUEL, Matthieu, MOIREAU, Philippe and CHAPELLE, Dominique, 2019. Stochastic modeling of chemical–mechanical coupling in striated muscles. Biomechanics and Modeling in Mechanobiology. 2019. Vol. 18, no. 3, p. 563–587. DOI 10.1007/s10237-018-1102-z.
  8. CARUEL, Matthieu and TRUSKINOVSKY, Lev, 2018. Physics of muscle contraction. Reports on Progress in Physics. 2018. Vol. 81, no. 3, p. 036602. DOI gf8wq6.
  9. CARUEL, Matthieu and TRUSKINOVSKY, Lev, 2017. Bi-stability resistant to fluctuations. Journal of the Mechanics and Physics of Solids. 2017. Vol. 109, p. 117–141. DOI gcgxxs.
  10. PRAKASH, Muthuramalingam, LEMAIRE, Thibault, CARUEL, Matthieu, LEWERENZ, Marius, DE LEEUW, Nora H., DI TOMMASO, Devis and NAILI, Salah, 2017. Anisotropic diffusion of water molecules in hydroxyapatite nanopores. Physics and Chemistry of Minerals. 2017. Vol. 44, no. 7, p. 509–519. DOI gbphjp.
  11. PRAKASH, Muthuramalingam, LEMAIRE, Thibault, DI TOMMASO, Devis, DE LEEUW, Nora, LEWERENZ, Marius, CARUEL, Matthieu and NAILI, Salah, 2017. Transport properties of water molecules confined between hydroxyapaptite surfaces: A Molecular dynamics simulation approach. Applied Surface Science. 2017. Vol. 418, p. 296–301. DOI gmtzzr.
  12. CARUEL, Matthieu and TRUSKINOVSKY, Lev, 2016. Statistical mechanics of the Huxley-Simmons model. Physical Review E. 2016. Vol. 93, no. 6, p. 062407. DOI gkpp6d.
  13. CARUEL, Matthieu, ALLAIN, Jean-Marc and TRUSKINOVSKY, Lev, 2015. Mechanics of collective unfolding. Journal of the Mechanics and Physics of Solids. 2015. Vol. 76, p. 237–259. DOI f639qf.
  14. CARUEL, Matthieu, CHABINIOK, Radomir, MOIREAU, Philippe, LECARPENTIER, Yves and CHAPELLE, Dominique, 2014. Dimensional reductions of a cardiac model for effective validation and calibration. Biomechanics and Modeling in Mechanobiology. 2014. Vol. 13, no. 4, p. 897–914. DOI gmtzn6.
  15. CARUEL, Matthieu, ALLAIN, Jean-Marc and TRUSKINOVSKY, Lev, 2013. Muscle as a Metamaterial Operating Near a Critical Point. Physical Review Letters 2013. Vol. 110, no. 24, p. 248103. DOI gmtzn5.
  16. COSTA, Rémi, HAFSAOUI, Julien, ALMEIDA DE OLIVEIRA, Ana Paula, GROSJEAN, Arnaud, CARUEL, Matthieu, CHESNAUD, Anthony and THOREL, Alain, 2009. Tape casting of proton conducting ceramic material. Journal of Applied Electrochemistry. 2009. Vol. 39, no. 4, p. 485–495. DOI c935ch.

7.7.2 Conference proceedings and invited workshops

  1. CARUEL, Matthieu, CHAINTRON, Louis-Pierre, KIMMIG, François and MOIREAU, Philippe, 2024. Jump-Diffusion Stochastic Model of Actin-Myosin Interaction in Muscles. 29th Congress of the European Society of Biomechanics. 2024. Edimburgh, Great Britain,
  2. CARUEL, Matthieu, DETREZ, Fabrice, NAVIZET, Isabelle and MANEVY, Robin, 2022. Umbrella Sampling for the estimation of the free energy barrier of Pi release in Myosin. In: 27th congress of the european society of biomechanics. Online. Porto, Portugal. 2022. Available online
  3. MANEVY, Robin, CARUEL, Matthieu, DETREZ, Fabrice and NAVIZET, 2021. Identification of Free Energy Barriers Associated With Transition In Myosin cycle Using Umbrella Sampling. In: Workshop Les Houches Protein Dynamics. Online congress. 2021.
  4. MANEVY, Robin, DETREZ, Fabrice, NAVIZET, Isabelle and CARUEL, Matthieu, 2021. Étude mécanique d’une protéine du muscle. In: Journée Thématique Biomécanique et Biomatériaux F2M. online. 2021.
  5. KIMMIG, François, CARUEL, Matthieu and CHAPELLE, Dominique, 2020. Intrinsic regulation of muscle contraction. In: Virtual pysiological human 2020. Paris. 2020.
  6. KIMMIG, François, CARUEL, Matthieu, MOIREAU, Philippe and CHAPELLE, Dominique, 2019. Activation-Contraction Coupling In A Multiscale Heart Model. In: NITHIARASU, P, OHTA, M. and OSHIMA, M. (eds.), 6th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2019. Sendai, Japan. 2019.
  7. KIMMIG, François, CARUEL, Matthieu and CHAPELLE, Dominique, 2018. A chemo-mechanical muscle model incorporating the power stroke into huxley’57 equations. In: World congress of biomechanics. Dublin, Ireland. 2018.
  8. MANCA, Fabio, PINCET, Frederic, TRUSKINOVSKY, Lev, ROTHMAN, James E, FORET, Lionel and CARUEL, Matthieu, 2018. Optimal number of SNARE proteins for fast neurotransmetter release. In: World congress of biomechanics. Dublin, Ireland. 2018.
  9. MANCA, Fabio, CARUEL, Matthieu, FORET, Lionel, PINCET, Frederic and ROTHMAN, James E, 2017. Mechanics of Neurotransmission. 2017. New Heaven, USA: J. Rothman Lab Retreat.
  10. TARANTINO, Gabriella, CARUEL, Matthieu and DANAS, Kostas, 2017. Buckling response of architectured columns: controlling instability across the scales through a rational design. In: 13e colloque national en calcul des structures. Giens, Var, France. 2017. Available online
  11. WIJANTO, Florent, CARUEL, Matthieu and ALLAIN, Jean-Marc, 2017. Modeling fiber interface with stochastic cross-bridges. In: European biophysics journal with biophysics letters. 2017. p. S247. Available online
  12. WIJANTO, Florent, CARUEL, Matthieu and ALLAIN, Jean-Marc, 2016. Soft biological tissues as fiber networks with probabilistic crosslinks. In:* 22nd congress of the european society of biomechanics*. Lyon. 2016. Available online
  13. CARUEL, Matthieu, 2015. Stochastic modeling of muscle contraction: Passive mechanisms. In Invited Workshop: Mathematical physiology of cardiac skeletal and smooth muscles. Pisa. 2015.
  14. CARUEL, Matthieu, CHAPELLE, Dominique and MOIREAU, Philippe, 2015. Thermodynamical framework for modeling chemical-mechanical coupling in muscle contraction - Formulation and validation . In: LACM. 2015.
  15. CARUEL, Matthieu, CHAPELLE, Dominique and MOIREAU, Philippe, 2015a. Thermodynamical Framework for Modeling Chemical-Mechanical Coupling in Muscle Contraction Formulation and Validation. In: Congrès français de mécanique. 2015.
  16. CARUEL, Matthieu and TRUSKINOVSKY, Lev, 2015. Huxley-Simmons model revisited. In: NITHIARASU, P and BUDYN, E (eds.), 4th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2015. 2015.
  17. CARUEL, Matthieu, CHABINIOK, Radomir, MOIREAU, Philippe, LECARPENTIER, Y and CHAPELLE, Dominique, 2013. Dimensional Reduction of Cardiac Models for Effective Validation and Calibration. In: 7th international conference on functional imaging and modeling of the heart, FIMH. Berlin, Heidelberg: Springer-Verlag. 2013. p. 259–267. Available online.
  18. CARUEL, Matthieu, TRUSKINOVSKY, Lev and ALLAIN, Jean-Marc, 2011. Myosin power-stroke in hard and soft device. In: Biophysical meeting. Baltimore, USA. 2011. p. 1–1.

7.7.3 PhD thesis

Caruel, Matthieu, 2011. Mechanics of Fast Force Recovery in Striated Muscles download. ÉcolePolytechnique

7.8 Awards

2008
Winner of the Monge Excellence PhD fellowship, Ecole Polytechnique, 2008.
2015
Overseas Talent Award (M. Caruel hails from the French department of Réunion island)
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